GPX1 (Human) Recombinant Protein
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Specification
Product Description
Human GPX1 (NP_000572, 1 a.a. - 203 a.a., U49C) full-length recombinant protein with His tag expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLCGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
Host
Escherichia coli
Theoretical MW (kDa)
24.2
Form
Liquid
Preparation Method
Escherichia coli expression system
Concentration
0.5 mg/mL
Purity
> 90% by SDS-PAGE
Quality Control Testing
15% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 20 mM Tris-HCl buffer, 100 mM NaCl, pH 8.0 (30% glycerol, 2 mM DTT).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — GPX1
Entrez GeneID
2876Protein Accession#
NP_000572Gene Name
GPX1
Gene Alias
GSHPX1, MGC14399, MGC88245
Gene Description
glutathione peroxidase 1
Omim ID
138320Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
cellular glutathione peroxidase
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Interactome
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Disease
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