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CASP10 (Human) Recombinant ProteinBioActive

  • Catalog # : P4252
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  • Specification
  • Product Description:
  • Human CASP10 (Q92851) recombinant protein expressed in Escherichia coli. This protein is composed of two small (11 KDa) subunits and two large (18 KDa) subunits in a heterotetramer form.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 58
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • >= 90% by SDS-PAGE
  • Activity:
  • > 8000 units/mg
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -80°C on dry atmosphere.
    After reconstitution with PBS containing 15% glycerol 1 uL per unit, store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 843
  • Gene Name:
  • CASP10
  • Gene Alias:
  • ALPS2,FLICE2,MCH4
  • Gene Description:
  • caspase 10, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • FADD-like ICE2,Fas-associated death domain protein,ICE-like apoptotic protease 4,apoptotic protease MCH-4,caspase 10,caspase 10, apoptosis-related cysteine protease,interleukin-1B-converting enzyme 2
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