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Last updated: 2017/11/19

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PRKACA (Human) Recombinant ProteinBioActive

  • Catalog # : P4226
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  • Specification
  • Product Description:
  • Human PRKACA (NM_002730) full-length recombinant protein with GST expressed in Sf9 cells.
  • Host:
  • Insect
  • Theoretical MW (kDa):
  • 69
  • Form:
  • Liquid
  • Purity:
  • >= 90% by SDS-PAGE
  • Activity:
  • 137 nmol phosphate incorporated into Histone H1 per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 uM ATP (0.83 uCi/assay).
  • Quality Control Testing:
  • 1 ug/lane SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4226
  • Storage Buffer:
  • In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.25 mM Dithiothreitol, 0.1 mM EGTA, 0.1 mM EDTA, 25% glycerol, 0.1 mM PMSF)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 5566
  • Gene Name:
  • PRKACA
  • Gene Alias:
  • MGC102831,MGC48865,PKACA
  • Gene Description:
  • protein kinase, cAMP-dependent, catalytic, alpha
  • Gene Summary:
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • PKA C-alpha,cAMP-dependent protein kinase catalytic subunit alpha,cAMP-dependent protein kinase catalytic subunit alpha, isoform 1,protein kinase A catalytic subunit
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