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IL24 (Human) Recombinant ProteinBioActive

  • Catalog # : P4173
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  • Specification
  • Product Description:
  • Human IL24 (Q13007, 158 amino acids) partial recombinant protein expressed in Saccharomyces cerevisiae.
  • Host:
  • Yeast
  • Theoretical MW (kDa):
  • 19.5
  • Form:
  • Lyophilized
  • Preparation Method:
  • Saccharomyces cerevisiae expression system
  • Purity:
  • >= 98% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug
  • Activity:
  • Measured by its ability to bind to the cell receptor of Capan-1 cells line resulted in Stat-3 activation.The ED50 for this effect is typically 1.0 ng/mL.
  • Storage Buffer:
  • Lyophilized from PBS (with BSA)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Gene Name:
  • IL24
  • Gene Alias:
  • C49A,FISP,IL-24,IL10B,MDA7,Mob-5,ST16,mda-7
  • Gene Description:
  • interleukin 24
  • Gene Summary:
  • This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • IL-24 splice variant delE3,IL-24 splice variant delE5,OTTHUMP00000034620,melanoma differentiation association protein 7,suppression of tumorigenicity 16 (melanoma differentiation)
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