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LBP (Human) Recombinant ProteinBioActive

  • Catalog # : P4166
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  • Specification
  • Product Description:
  • Human LBP (P18428) full-length recombinant protein expressed in CHO cells.
  • Host:
  • Hamster
  • Theoretical MW (kDa):
  • 58
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (CHO) expression system
  • Purity:
  • >= 90-95% by SDS-PAGE
  • Endotoxin Level:
  • < 0.03 ng/mL
  • Activity:
  • Up to 0.2 ug/ mL LBP mediates binding of FITC-LPS (0.5ug/mL) to CD14+CHO transfectants (FACS).
  • Storage Buffer:
  • Lyophilized from 1X PBS, pH 7.1
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with ultra-pure distilled water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 3929
  • Gene Name:
  • LBP
  • Gene Alias:
  • MGC22233
  • Gene Description:
  • lipopolysaccharide binding protein
  • Gene Summary:
  • The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq
  • Other Designations:
  • LPS-binding protein,OTTHUMP00000030965,lipopolysaccharide-binding protein
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