Human BMPR1A (P36894) partial recombinant protein expressed in Sf9 cells.
Theoretical MW (kDa):
Insect cell (Sf9) expression system
>= 90% by SDS-PAGE and HPLC
Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells.The ED50 for this effect is typically 1-3 ug/mL in the presence of 500 ng/mL of recombinant human BMP-2.
Lyophilized from 1X PBS
Store at -20°C on dry atmosphere. After reconstitution with sterilized PBS, store at -20°C. Aliquot to avoid repeated freezing and thawing.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq
OTTHUMP00000020014,activin A receptor, type II-like kinase 3