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HGF (Human) Recombinant ProteinBioActive

  • Catalog # : P4085
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  • Specification
  • Product Description:
  • Human HGF (heterodimer) (P14210, alpha chain 463 amino acids, beta chain 234 amino acids) recombinant protein expressed in Hi-5 cells.
  • Host:
  • Insect
  • Theoretical MW (kDa):
  • 78
  • Form:
  • Lyophilized
  • Preparation Method:
  • Insect cell (Hi-5) expression system
  • Purity:
  • >= 98% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug
  • Activity:
  • The ED50 determined by the scattering activity in the MDCK cell assay is typically at 0.5-1.0 ng/mL.
  • Storage Buffer:
  • Lyophilized from 50 mM acetic acid
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 3082
  • Gene Name:
  • HGF
  • Gene Alias:
  • Gene Description:
  • hepatocyte growth factor (hepapoietin A; scatter factor)
  • Gene Summary:
  • Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • fibroblast-derived tumor cytotoxic factor,hepatocyte growth factor,hepatopoietin A,lung fibroblast-derived mitogen,scatter factor
  • Interactome
  • Interactome
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