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TNFSF9 (Human) Recombinant ProteinBioActive

  • Catalog # : P4065
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  • Specification
  • Product Description:
  • Human TNFSF9 (P41273, 185 amino acids) partial recombinant protein expressed in Escherichia coli.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 19.5
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • >= 98% by SDS-PAGE
  • Endotoxin Level:
  • < 0.1 ng/ug
  • Activity:
  • Determined by the dose-dependent stimulation of IL-8 production by human PBMC.The ED50 for the effect is less than 10 ng/mL.
  • Storage Buffer:
  • Lyophilized from 5 mM Tris, 75 mM NaCl, pH 8.0
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 8744
  • Gene Name:
  • TNFSF9
  • Gene Alias:
  • 4-1BB-L,CD137L
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 9
  • Gene Summary:
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction
  • Other Designations:
  • homolog of mouse 4-1BB-L,receptor 4-1BB ligand
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