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CASP8 (Human) Recombinant ProteinBioActive

  • Catalog # : P4039
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  • Specification
  • Product Description:
  • Human CASP8 (Q14790) recombinant protein expressed in Escherichia coli.
  • Host:
  • Escherichia coli
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • >= 95% by SDS-PAGE
  • Activity:
  • > 5000 units/mg
  • Quality Control Testing:
  • Western Blot Analysis

    QC Testing of P4039
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -80°C on dry atmosphere.
    After reconstitution with PBS containing 15% glycerol 1 uL per unit, store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 841
  • Gene Name:
  • CASP8
  • Gene Alias:
  • Gene Description:
  • caspase 8, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
  • Other Designations:
  • FADD-homologous ICE/CED-3-like protease,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,Mch5 isoform alpha,OTTHUMP00000163718,OTTHUMP00000163719,OTTHUMP00000163720,caspase 8,caspase 8, apoptosis-related cysteine protease,cysteine protease,procaspase-8
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