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CASP1 (Human) Recombinant ProteinBioActive

  • Catalog # : P4033
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  • Specification
  • Product Description:
  • Human CASP1 (NP_150634.1, 120 a.a. - 404 a.a.) partial recombinant protein expressed in Escherichia coli. This protein is composed of one small (10 KDa) and one large (20 KDa) subunit.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 30
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Activity:
  • > 5000 units/mg
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -80°C on dry atmosphere.
    After reconstitution with PBS containing 15% glycerol 1 uL per unit, store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 834
  • Gene Name:
  • CASP1
  • Gene Alias:
  • ICE,IL1BC,P45
  • Gene Description:
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
  • Other Designations:
  • CASP1 nirs variant 1,IL1B-convertase,caspase 1,caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase),interleukin 1-B converting enzyme,interleukin 1-beta convertase
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