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IL12A (Human) Recombinant ProteinBioActive

  • Catalog # : P3997
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  • Specification
  • Product Description:
  • Human IL12A (P29459, 503 amino acids) partial recombinant protein expressed in CHO cells.
  • Host:
  • Hamster
  • Theoretical MW (kDa):
  • 75
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (CHO) expression system
  • Purity:
  • >= 98% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug
  • Activity:
  • The ED50 was determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
  • Storage Buffer:
  • Lyophilized in 0.5X PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with PBS, store at 4°C for 1 week or -20°C for longer.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3592
  • Gene Name:
  • IL12A
  • Gene Alias:
  • CLMF,IL-12A,NFSK,NKSF1,P35
  • Gene Description:
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
  • Gene Summary:
  • This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq
  • Other Designations:
  • IL-12, subunit p35,NF cell stimulatory factor chain 1,cytotoxic lymphocyte maturation factor 1, p35,interleukin 12, p35,interleukin 12A,interleukin-12 alpha chain,natural killer cell stimulatory factor 1, 35 kD subunit
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