LIFR (Human) Recombinant Protein
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Specification
Product Description
Human LIFR (P42702, Gln 45 - Ser 833) partial recombinant protein expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
125-135
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Storage Buffer
Lyophilized from PBS, pH 7.2
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at 4°C for one month. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — LIFR
Entrez GeneID
3977Protein Accession#
P42702Gene Name
LIFR
Gene Alias
CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS
Gene Description
leukemia inhibitory factor receptor alpha
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CD118 antigen|leukemia inhibitory factor receptor
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