CCL2 (Human) Recombinant Protein
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Specification
Product Description
Human CCL2 (P13500, 24 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Host
Escherichia coli
Theoretical MW (kDa)
9
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Activity
Determined by the ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/mL.
Storage Buffer
Lyophilized from 0.02 M Tris-HCl, pH 7.5 (20% glycerol)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at 4°C for one month. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CCL2
Entrez GeneID
6347Protein Accession#
P13500Gene Name
CCL2
Gene Alias
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Gene Description
chemokine (C-C motif) ligand 2
Gene Ontology
HyperlinkGene Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq
Other Designations
monocyte chemoattractant protein-1|monocyte chemotactic and activating factor|monocyte chemotactic protein 1, homologous to mouse Sig-je|monocyte secretory protein JE|small inducible cytokine A2|small inducible cytokine A2 (monocyte chemotactic protein 1,
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Interactome
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Disease
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