The ED50 was determined by the dose dependent proliferation of murine BALB/c 3T3 cells (measured by3H-thymidine uptake), and was found to be less than 0.1 ng/mL. , corresponding to a specific activity of >1.0 x 107 units/mg.
Lyophilized from PBS, pH 7.2
Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq
T cell growth factor,aldesleukin,interleukin-2,involved in regulation of T-cell clonal expansion