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IL18 (Human) Recombinant ProteinBioActive

  • Catalog # : P3632
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  • Specification
  • Product Description:
  • Human IL18 (Q14116, 37 a.a. - 193 a.a.) partial recombinant protein expressed in Escherichia coli.
  • Sequence:
  • ENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 18
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purification:
  • Ion exchange column and HPLC reverse phase column
  • Purity:
  • > 90% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug (1 EU/ug)
  • Activity:
  • The ED50 was determined by the dose-dependent proliferation of human PBMC co-stimulated with IL-12 cells was found to be in the range of 5 ng/mL.
  • Storage Buffer:
  • Lyophilized from PBS
  • Storage Instruction:
  • Store at -20°C.
    Please reconstitution with 8 M Urea and 10 mM Tris-HCl (pH8.0) Buffer.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3606
  • Gene Name:
  • IL18
  • Gene Alias:
  • IGIF,IL-18,IL-1g,IL1F4,MGC12320
  • Gene Description:
  • interleukin 18 (interferon-gamma-inducing factor)
  • Gene Summary:
  • The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq
  • Other Designations:
  • IL-1 gamma,interferon-gamma-inducing factor,interleukin 18,interleukin-1 gamma,interleukin-18
  • Related Disease
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