MSTN (Human) Recombinant Protein
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Specification
Product Description
Human MSTN (O14793, 267 a.a. - 375 a.a.) partial recombinant protein. expressed in Escherichia coli.
Sequence
DFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Host
Escherichia coli
Theoretical MW (kDa)
25 (non-reducing)
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Activity
The ED50 was determined by the dose-dependent proliferation inhibition of human MPC-11 cells was found to be in the range of 20.0-40.0 ng/mL.
Storage Buffer
Lyophilized from Tris, pH 8.0
Storage Instruction
Store at -20°C on dry atmosphere for 2 years.
After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — MSTN
Entrez GeneID
2660Protein Accession#
O14793Gene Name
MSTN
Gene Alias
GDF8
Gene Description
myostatin
Omim ID
601788Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq
Other Designations
growth differentiation factor 8
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