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TNFRSF13C (Human) Recombinant ProteinBioActive

  • Catalog # : P3588
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  • Specification
  • Product Description:
  • Human TNFRSF13C (Q96RJ3, 1 a.a. - 79 a.a.) partial recombinant protein expressed in Escherichia coli.
  • Sequence:
  • MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASSPAPRTALQPQESVGAGAGEAALPLPGLL
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 9
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purification:
  • Ion exchange column and HPLC reverse phase column
  • Purity:
  • > 90% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug (1 EU/ug)
  • Activity:
  • The ED50 was determined by the ability to block BAFF induced survival of splenocyte cells, and was found to be in the range of 1.0-5.0 ug/mL.
  • Storage Buffer:
  • Lyophilized from 2.5% glycine, 0.5% sucrose, 0.01% Tween 80, 5 mM Glutamic acid, pH 4.5
  • Storage Instruction:
  • Store at -20°C on dry atmosphere for 2 years.
    After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Gene Name:
  • TNFRSF13C
  • Gene Alias:
  • BAFF-R,BAFFR,CD268,MGC138235
  • Gene Description:
  • tumor necrosis factor receptor superfamily, member 13C
  • Gene Summary:
  • B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq
  • Other Designations:
  • B cell-activating factor receptor,BAFF receptor,OTTHUMP00000028746
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