PPIB (Human) Recombinant Protein
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Specification
Product Description
Human PPIB (NP_000933, 26 a.a. - 216 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
MLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Host
Escherichia coli
Theoretical MW (kDa)
21.2
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
Conventional Chromatography
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Activity
Specific activity is > 220 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25°C in Tris-HCl pH 8.0 using chymotrypsin.
Quality Control Testing
Loading 3 ug protein in 15% SDS-PAGE
Storage Buffer
In 20 mM Tris, 20 mM NaCl, pH 8.0 (0.5 mM DTT, 10% glycerol).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — PPIB
Entrez GeneID
5479Protein Accession#
NP_000933Gene Name
PPIB
Gene Alias
CYP-S1, CYPB, MGC14109, MGC2224, SCYLP
Gene Description
peptidylprolyl isomerase B (cyclophilin B)
Omim ID
123841Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. [provided by RefSeq
Other Designations
PPIase|S-cyclophilin|cyclophilin B|cyclophilin-like protein|peptidyl-prolyl cis-trans isomerase B|peptidylprolyl isomerase B|rotamase
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Interactome
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Disease
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