GDF5 (Human) Recombinant Protein
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Specification
Product Description
Human GDF5 (NP_000548, 382 a.a. - 501 a.a.) partial recombinant protein with His tag at N-terminal expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
Host
Escherichia coli
Theoretical MW (kDa)
15.8
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
This product was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration
0.5 mg/mL
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Quality Control Testing
Loading 3 ug protein in 15% SDS-PAGE
Storage Buffer
In 10 mM Sodium Citrate buffer, pH 3.5 (10% glycerol).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — GDF5
Entrez GeneID
8200Protein Accession#
NP_000548Gene Name
GDF5
Gene Alias
BMP14, CDMP1, LAP4, SYNS2
Gene Description
growth differentiation factor 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq
Other Designations
OTTHUMP00000030755|OTTHUMP00000061644|cartilage-derived morphogenetic protein-1
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