CEBPA (Human) Recombinant Protein
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Specification
Product Description
Human CEBPA (NP_004355, 270 a.a. - 358 a.a.) partial recombinant protein with His tag expressed in Escherichia coli.
Sequence
MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA
Host
Escherichia coli
Theoretical MW (kDa)
14.5
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
Ion-exchange chromatography and FPLC gel-filtration chromatography
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Quality Control Testing
Loading 3 ug protein in 15% SDS-PAGE
Storage Buffer
In 20 mM Tris-HCl buffer, 0.1 M NaCl, pH 7.5 (5 mM beta-Mercaptoethanol).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — CEBPA
Entrez GeneID
1050Protein Accession#
NP_004355Gene Name
CEBPA
Gene Alias
C/EBP-alpha, CEBP
Gene Description
CCAAT/enhancer binding protein (C/EBP), alpha
Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq
Other Designations
CCAAT/enhancer binding protein alpha
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Interactome
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