FLT3 monoclonal antibody, clone BV10A4 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native FLT3.
Immunogen
Native purified FLT3 from BV-173 leukemic cell line.
Host
Mouse
Theoretical MW (kDa)
130-160
Reactivity
Human
Specificity
The mouse monoclonal antibody BV10A4 (BV10) reacts with FLT3 (CD135), a 130-160 kDa type III receptor tyrosine kinase that is involved in early steps of hematopoiesis.
Form
Liquid
Conjugation
PE
Purification
Size-exclusion chromatography purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 uL reagent/100 uL of whole blood or 106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.02% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — FLT3
Entrez GeneID
2322Gene Name
FLT3
Gene Alias
CD135, FLK2, STK1
Gene Description
fms-related tyrosine kinase 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
Other Designations
CD135 antigen|FL cytokine receptor|FLT3 receptor tyrosine kinase|OTTHUMP00000042340|fetal liver kinase 2|growth factor receptor tyrosine kinase type III|stem cell tyrosine kinase 1|tyrosine-protein kinase receptor FLT3
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