Formalin-fixed and paraffin-embedded human breast cancer tissue (A, 4 µm), human stomach adenocarcinoma (B, 4 µm), and human colon adenocarcinoma (C, 4 µm), stained with KRT8 monoclonal antibody, clone R15-K (Cat # MAB9771) shows strong positive cytoplasmic immunostaining of neoplastic cells (A), strong positive cytoplasmic immunostaining of tumor cells (B, C). Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq