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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human skin squamous cell carcinoma (A, 4 µm), prostate hyperplasia (B, 4 µm), and human tonsil tissue (C, 4 µm) stained with KRT14 monoclonal antibody, clone D19-N (Cat # MAB9766) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C).
Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.

Immunohistochemistry (Frozen sections)

Entrez GeneID

3861

Protein Accession#

P02533

Gene Name

KRT14

Gene Alias

CK14, EBS3, EBS4, K14, NFJ

Gene Description

keratin 14

Omim ID

125595 131800 148066 161000 601001

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq

Other Designations

cytokeratin 14|keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)