KRT14 monoclonal antibody, clone D19-N
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Specifications
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of KRT14.
Immunogen
A synthetic peptide corresponding to C-terminus of human KRT14.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skin squamous cell carcinoma (A, 4 µm), prostate hyperplasia (B, 4 µm), and human tonsil tissue (C, 4 µm) stained with KRT14 monoclonal antibody, clone D19-N (Cat # MAB9766) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C).
Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.Immunohistochemistry (Frozen sections)
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Gene Info — KRT14
Entrez GeneID
3861Protein Accession#
P02533Gene Name
KRT14
Gene Alias
CK14, EBS3, EBS4, K14, NFJ
Gene Description
keratin 14
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq
Other Designations
cytokeratin 14|keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
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Interactomes
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Diseases
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Publication Reference
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Endoscopic cell sheet transplantation device developed by using a 3-dimensional printer and its feasibility evaluation in a porcine model.
Maeda M, Kanai N, Kobayashi S, Hosoi T, Takagi R, Ohki T, Muragaki Y, Yamato M, Eguchi S, Fukai F, Okano T.
Gastrointestinal Endoscopy 2015 Jul; 82(1):147.
Application:IHC, Pig, Epidermal keratinocytes.
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Endoscopic cell sheet transplantation device developed by using a 3-dimensional printer and its feasibility evaluation in a porcine model.
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