Product Browser

Last updated: 2016/12/4
  • Related Product Showcase

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

CCND1 monoclonal antibody, clone E16-I

  • Catalog # : MAB9765
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of CCND1.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human CCND1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:300)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human mantle cell lymphoma-lymph node tissue (4 µm) stained with CCND1 monoclonal antibody, clone E16-I (Cat # MAB9765) shows strong positive nuclear immunostaining of tumor cells.
    Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 595
  • Gene Name:
  • CCND1
  • Gene Alias:
  • BCL1,D11S287E,PRAD1,U21B31
  • Gene Description:
  • cyclin D1
  • Gene Summary:
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
  • Other Designations:
  • B-cell CLL/lymphoma 1,G1/S-specific cyclin D1
  • Related Disease
  • RSS
  • YouTube
  • Linkedin
  • Facebook