CD1A monoclonal antibody, clone L21-A
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skin cells (4 µm) stained with CD1A monoclonal antibody, clone L21-A (Cat # MAB9761) show strong positive immunostaining of Langerhans cells in epidermis.
Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovakia
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of CD1A.
Immunogen
A synthetic peptide corresponding to C-terminus of human CD1A.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skin cells (4 µm) stained with CD1A monoclonal antibody, clone L21-A (Cat # MAB9761) show strong positive immunostaining of Langerhans cells in epidermis.
Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, SlovakiaImmunohistochemistry (Frozen sections)
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Gene Info — CD1A
Entrez GeneID
909Protein Accession#
P06126Gene Name
CD1A
Gene Alias
CD1, FCB6, HTA1, R4, T6
Gene Description
CD1a molecule
Omim ID
188370Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD1A antigen|CD1A antigen, a polypeptide|OTTHUMP00000018907|T-cell surface antigen T6/Leu-6|T-cell surface glycoprotein CD1a|cluster of differentiation 1 A|cortical thymocyte antigen CD1A|differentiation antigen CD1-alpha-3|epidermal dendritic cell marker
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Interactome
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Pathway
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Disease
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