C3 monoclonal antibody, clone E28-P
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skin biopsy (4 µm) from lesion of the early pemphigus vulgaris (without blister formation), stained with C3 monoclonal antibody, clone E28-P (Cat # MAB9757) shows strong positive intraepidermal intercellular immunostaining.
Kindly performed and provided by Marian Svajdler, MD and Lucia Frohlichova, MD, from Louis Pasteur University Hospital Department of Pathology, Kosice, Slovak Republic.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of C3.
Immunogen
A synthetic peptide corresponding to N-terminus of human C3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skin biopsy (4 µm) from lesion of the early pemphigus vulgaris (without blister formation), stained with C3 monoclonal antibody, clone E28-P (Cat # MAB9757) shows strong positive intraepidermal intercellular immunostaining.
Kindly performed and provided by Marian Svajdler, MD and Lucia Frohlichova, MD, from Louis Pasteur University Hospital Department of Pathology, Kosice, Slovak Republic.Immunohistochemistry (Frozen sections)
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Gene Info — C3
Entrez GeneID
718Protein Accession#
P01024Gene Name
C3
Gene Alias
ARMD9, ASP, CPAMD1
Gene Description
complement component 3
Omim ID
120700Gene Ontology
HyperlinkGene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq
Other Designations
acylation-stimulating protein cleavage product|complement component C3
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Interactome
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Pathway
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Disease
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Publication Reference
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Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury.
De Hoog VC, Timmers L, Van Duijvenvoorde A, De Jager SC, Van Middelaar BJ, Smeets MB, Woodruff TM, Doevendans PA, Pasterkamp G, Hack CE, De Kleijn DP.
Cardiovascular Research 2014 Sep; 103(4):521.
Application：IHC-P, Mouse, Ventricles.
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Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury.
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