PAX5 monoclonal antibody, clone 1EW
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Specifications
Product Description
Mouse monoclonal antibody raised against partial recombinant PAX5.
Immunogen
Recombinant protein corresponding to C-terminus of human PAX5.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:20-1:40)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining for paraffin-embedded human acute lymphoblastic leukemia section using PAX5 monoclonal antibody, clone 1EW (Cat # MAB9628). Note nuclear staining of B cells. -
Gene Info — PAX5
Entrez GeneID
5079Gene Name
PAX5
Gene Alias
BSAP
Gene Description
paired box 5
Omim ID
167414Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq
Other Designations
B-cell lineage specific activator|paired box homeotic gene 5|transcription factor PAX 5
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