VIM monoclonal antibody, clone SRL33
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant VIM.
Immunogen
Recombinant protein corresponding to a portion at C-terminus of human VIM.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (1:400)
Western Blotting (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — VIM
Entrez GeneID
7431Gene Name
VIM
Gene Alias
FLJ36605
Gene Description
vimentin
Omim ID
193060Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract
Other Designations
OTTHUMP00000019224
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Interactome
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Disease
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Publication Reference
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Camille A McAloney, Rawan Makkawi, Yogesh Budhathoki, Matthew V Cannon, Emily M Franz, Amy C Gross, Maren Cam, Tatyana A Vetter, Rebekka Duhen, Alexander E Davies, Ryan D Roberts.
Cellular Oncology (Dordrecht) 2023 Sep; [Epub].
Application：IHC, Human, Human osteosarcoma, MG63.3, OS17 cells.
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Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization.
Sanjana Rajan, Emily M Franz, Camille A McAloney, Tatyana A Vetter, Maren Cam, Amy C Gross, Cenny Taslim, Meng Wang, Matthew V Cannon, Alexander Oles, Ryan D Roberts.
BMC Biology 2023 Apr; 21(1):98.
Application：IF, Human, 143B, OS-17 cells.
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
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