MYOT monoclonal antibody, clone RSO34
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MYOT.
Immunogen
Recombinant protein corresponding to 266 amino acids at C-terminus of human MYOT.
Host
Mouse
Reactivity
Human
Form
Lyophilized
Isotype
IgG1, kappa
Recommend Usage
Immunohistochemistry (Frozen sections) (1:20)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:40-1:80)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with steril distilled water, Store at 4°C for at least two months.
For long term storage store at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining for paraffin-embedded human skeletal muscle section using MYOT monoclonal antibody, clone RSO34 (Cat # MAB9563). Note intense staining of muscle fibers.Immunohistochemistry (Frozen sections)
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Gene Info — MYOT
Entrez GeneID
9499Gene Name
MYOT
Gene Alias
LGMD1, LGMD1A, TTID
Gene Description
myotilin
Gene Ontology
HyperlinkGene Summary
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined
Other Designations
titin immunoglobulin domain protein (myotilin)
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Interactome
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Disease
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