EZH2 monoclonal antibody, clone 6A10
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant EZH2.
Immunogen
Recombinant protein corresponding N-terminus of human EZH2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:200)
Western Blot (1:25-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
-
Gene Info — EZH2
Entrez GeneID
2146Gene Name
EZH2
Gene Alias
ENX-1, EZH1, KMT6, MGC9169
Gene Description
enhancer of zeste homolog 2 (Drosophila)
Omim ID
601573Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
enhancer of zeste 2
-
Interactome
-
Disease
-
Publication Reference
-
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma.
Till Eichenauer, Luca Simmendinger, Christoph Fraune, Tim Mandelkow, Niclas C Blessin, Martina Kluth, Claudia Hube-Magg, Katharina Möller, Till Clauditz, Sören Weidemann, Roland Dahlem, Margit Fisch, Silke Riechardt, Ronald Simon, Guido Sauter, Franziska Büscheck, Michael Rink.
World Journal of Urology 2021 Feb; 39(2):481.
Application：IHC-P, Human, Human renal cell carcinoma.
-
Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.
Segovia C, San José-Enériz E, Munera-Maravilla E, Martínez-Fernández M, Garate L, Miranda E, Vilas-Zornoza A, Lodewijk I, Rubio C, Segrelles C, Valcárcel LV, Rabal O, Casares N, Bernardini A, Suarez-Cabrera C, López-Calderón FF, Fortes P, Casado JA, Dueñas M, Villacampa F, Lasarte JJ, Guerrero-Ramos F, de Velasco G, Oyarzabal J, Castellano D, Agirre X, Prósper F, Paramio JM.
Nature Medicine 2019 Jul; 25(7):1073.
Application：IHC-P, WB-Ce, WB-Ti, WB-Tr, Human, Mouse, Mouse xenograft tumors, RT112 cells.
-
Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters.
Nathaniel Melling, Erik Thomsen, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Stefan Steurer, Till Krech.
Carcinogenesis 2015 Nov; 36(11):1333.
Application：IHC, Quant, Human, Human prostate.
-
In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.
Mirentxu Santos, Monica Martinez-Fernandez, Marta Duenas, Ramon Garcia-Escudero, Begona Alfaya, Felipe Villacampa, Cristina Saiz-Ladera, Clotilde Costa, Marta Oteo, Jose Duarte, Victor Martinez, M Jose Gomez-Rodriguez, M Luisa Martín, Manoli Fernandez, Patrick Viatour, Miguel A Morcillo, Julien Sage, Daniel Castellano, Jose L Rodriguez-Peralto, Federico de la Rosa, Jesus M Paramio.
Cancer Research 2014 Nov; 74(22):6565.
-
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com