HIRA monoclonal antibody, clone WC119.2H11
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis in Lane 1: 293 cells transfected with HIRA and Lane 2: 293 cells transfected withoud HIRA with HIRA monoclonal antibody, clone WC119.2H11 (Cat # MAB8967).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant HIRA.
Amount
100 uL
Immunogen
Recombinant protein corresponding to amino acids 421-729 of human HIRA.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with human HIRA.
Form
Liquid
Purification
Purified ascites
Concentration
1 ug/uL
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Transfected lysate)
Western blot analysis in Lane 1: 293 cells transfected with HIRA and Lane 2: 293 cells transfected withoud HIRA with HIRA monoclonal antibody, clone WC119.2H11 (Cat # MAB8967). -
Gene Info — HIRA
Entrez GeneID
7290Gene Name
HIRA
Gene Alias
DGCR1, TUP1, TUPLE1
Gene Description
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
Omim ID
600237Gene Ontology
HyperlinkGene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq
Other Designations
DiGeorge critical region gene 1|HIR histone cell cycle regulation defective homolog A
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Interactome
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Disease
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Publication Reference
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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
Bakail M, Gaubert A, Andreani J, Moal G, Pinna G, Boyarchuk E, Gaillard MC, Courbeyrette R, Mann C, Thuret JY, Guichard B, Murciano B, Richet N, Poitou A, Frederic C, Le Du MH, Agez M, Roelants C, Gurard-Levin ZA, Almouzni G, Cherradi N, Guerois R, Ochsenbein F.
Cell Chemical Biology 2019 Nov; 26(11):1573.
Application：WB-Tr, Human, U2OS cells.
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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
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