Western blot analysis of MCL1 monoclonal antibody, clone MCL.C9 (Cat # MAB8825) in mouse B-cell lymphoma mouse transgenic model (lymph nodes from different mouse). The upper bands represent 3 separate diseased lympho nodes and the spleen from the same transgenic mouse (Lane 1-4), along with lymphoid tissue from a nontransgenic littermate (Lane 5).
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq