SRY protein was immunoprecipitated from 1 mg total mouse XY testes (Lane 1) or mesonephros (Lane 2) tissue with a rabbit anti SRY antibody, followed by western blot analysis using SRY monoclonal antibody, clone SRY.G12 (Cat # MAB8814).
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq
OTTHUMP00000034324,essential protein for sex determination in human males,sex determining region protein,sex-determining region on Y,testis-determining factor