CCND1 monoclonal antibody, clone 0c65
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CCND1.
Immunogen
Recombinant protein corresponding to full length human CCND1.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes recombinant protein CCND1.
Form
Liquid
Purification
Affinity purification
Concentration
1 ug/uL
Isotype
IgG2b
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In citrate-Tris-HCl, pH 7.0 (0.02% Proclin 300)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Recombinant protein)
Western blot analysis in CCND1 recombinant protein with CCND1 monoclonal antibody, clone 0c65 (Cat # MAB8798) at 1 : 1000 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCND1
Entrez GeneID
595Protein Accession#
NM_053056.2Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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