ABCA1 monoclonal antibody, clone AB.H10
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ABCA1.
Immunogen
A synthetic peptide corresponding to amino acids 1800-2260 at C-terminus end of human ABCA1.
Host
Mouse
Reactivity
Chicken, Human, Mouse
Form
Liquid
Purification
Protein A purification
Concentration
1 ug/uL
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ABCA1 induction by cholesterol (+) in human fibroblast cells from different patients (1, 2, 3, 4). Simultaneous bloting with anti-actin antibody was used for protein loading control.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ABCA1
Entrez GeneID
19Gene Name
ABCA1
Gene Alias
ABC-1, ABC1, CERP, FLJ14958, HDLDT1, MGC164864, MGC165011, TGD
Gene Description
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq
Other Designations
ATP binding cassette transporter 1|ATP-binding cassette 1|ATP-binding cassette, sub-family A member 1|OTTHUMP00000021833|cholesterol efflux regulatory protein|membrane-bound
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Interactome
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Pathway
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Disease
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