Als2 monoclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of Als2 monoclonal antibody (Cat # MAB8764) in mouse neuronal tissue : brain stem (Lane 1), cerebellum (Lane 2) and cortex (Lane 3) transfected with full length Als2-EGFP fusion construct (expected size 220 KDa).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant Als2.
Immunogen
Recombinant protein corresponding to amino acids 221-321 of mouse Als2.
Sequence
PSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSS
Host
Mouse
Reactivity
Mouse
Form
Liquid
Purification
Affinity purification
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Als2 monoclonal antibody (Cat # MAB8764) in mouse neuronal tissue : brain stem (Lane 1), cerebellum (Lane 2) and cortex (Lane 3) transfected with full length Als2-EGFP fusion construct (expected size 220 KDa). -
Gene Info — ALS2
Entrez GeneID
57679Gene Name
ALS2
Gene Alias
ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ
Gene Description
amyotrophic lateral sclerosis 2 (juvenile)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
alsin
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Interactome
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Pathway
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Disease
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