GZMB monoclonal antibody, clone CLB-GB11
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Specification
Product Description
Mouse monoclonal antibody raised against full length native GZMB.
Immunogen
Native purified GZMB from human NK cell line YT-INDY.
Host
Mouse
Reactivity
Human, Non-Human Primates
Specificity
This antibody is specific to GZMB.
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In TBS, pH 8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — GZMB
Entrez GeneID
3002Gene Name
GZMB
Gene Alias
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Gene Description
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Omim ID
123910Gene Ontology
HyperlinkGene Summary
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq
Other Designations
T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic serine protease B|fragmentin 2|granzyme B
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Interactome
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Pathway
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Disease
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Publication Reference
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Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
Martin P, Pardo J, Schill N, Jockel L, Berg M, Froelich CJ, Wallich R, Simon MM.
Journal of Biological Chemistry 2010 Jun; 285(24):18918.
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Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Sun Y, Schmitz JE, Acierno PM, Santra S, Subbramanian RA, Barouch DH, Gorgone DA, Lifton MA, Beaudry KR, Manson K, Philippon V, Xu L, Maecker HT, Mascola JR, Panicali D, Nabel GJ, Letvin NL.
Journal of Immunology 2005 Apr; 174(8):4753.
Application:Flow Cyt, Monkey, Rhesus monkey CD4 T lymphocytes.
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Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.
Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Peronne C, de Saint Vis B, Briere F, Bates EE.
Blood 2002 Nov; 100(9):3295.
Application:Flow Cyt, Human, PDCs, MDDCs, Monocytes.
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Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
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