LDHA monoclonal antibody, clone AT1A4
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Jurkat cell lysate, Lane 2: 293T cell lysate, Lane 3: A431 cell lysate, Lane 4: HeLa cell lysate.
Immunofluorescence
Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and LDHA monoclonal antibody, clone AT1A4 (Cat # MAB8700) (1 : 500) with Texas Red (Red).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant LDHA.
Immunogen
Recombinant protein corresponding to full length human LDHA.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Concentration
1 mg/mL
Isotype
IgG2b, kappa
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Jurkat cell lysate, Lane 2: 293T cell lysate, Lane 3: A431 cell lysate, Lane 4: HeLa cell lysate.Immunocytochemistry
Immunofluorescence
Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and LDHA monoclonal antibody, clone AT1A4 (Cat # MAB8700) (1 : 500) with Texas Red (Red).Enzyme-linked Immunoabsorbent Assay
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Gene Info — LDHA
Entrez GeneID
3939Protein Accession#
NP_005557Gene Name
LDHA
Gene Alias
LDH-M, LDH1, PIG19
Gene Description
lactate dehydrogenase A
Omim ID
150000Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq
Other Designations
L-lactate dehydrogenase A|proliferation-inducing gene 19
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV.
PNAS 2010 Jan; 107(5):2037.
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The ldhA gene, encoding fermentative L-lactate dehydrogenase of Corynebacterium glutamicum, is under the control of positive feedback regulation mediated by LldR.
Toyoda K, Teramoto H, Inui M, Yukawa H.
Journal of Bacteriology 2009 May; 191(13):4251.
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LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.
Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, Sukhatme VP, Seth P.
Molecular Cancer Therapeutics 2009 Mar; 8(3):626.
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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.
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