IL25 monoclonal antibody, clone SB129a
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant IL25.
Immunogen
Recombinant protein corresponding to full length human IL25.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to native/recombinant IL-25.
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (0.1-1 ug/mL)
Immunostaining (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In BBS, pH8.2
Storage Instruction
Store at 4°C.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL25
Entrez GeneID
64806Gene Name
IL25
Gene Alias
IL-17E, IL-25, IL17E
Gene Description
interleukin 25
Omim ID
605658Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
interleukin 17E
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Interactome
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Pathway
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Publication Reference
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Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB.
Stock P, Lombardi V, Kohlrautz V, Akbari O.
Journal of Immunology (Baltimore, Md. : 1950) 2009 Apr; 182(8):5116.
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On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites.
Perrigoue JG, Marshall FA, Artis D.
Cellular Microbiology 2008 Sep; 10(9):1757.
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IL-25 regulates Th17 function in autoimmune inflammation.
Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ.
The Journal of Experimental Medicine 2007 Jan; 204(1):161.
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Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.
Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN.
The Journal of Experimental Medicine 2006 Apr; 203(4):1105.
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IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, Muchamuel T, Hurst SD, Zurawski G, Leach MW, Gorman DM, Rennick DM.
Immunity 2001 Dec; 15(6):985.
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Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB.
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