FAM175A monoclonal antibody, clone ABRA1-01
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant FAM175A.
Immunogen
Recombinant His fusion protein corresponding to amino acids 1-313 of human FAM175A.
Host
Mouse
Reactivity
Human
Specificity
This antibody is spevific to N-terminal part of FAM175A.
Form
Liquid
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Flow cytometry (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Flow Cytometry
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Gene Info — FAM175A
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Interactome
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Disease
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Publication Reference
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Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.
Nikkila J, Coleman KA, Morrissey D, Pylkas K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA.
Oncogene 2009 Mar; 28(16):1843.
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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.
Wang B, Elledge SJ.
PNAS 2007 Dec; 104(52):20759.
Application:IF, IP, WB-Tr, Human, HEK 293T, U-2 OS cells.
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CCDC98 targets BRCA1 to DNA damage sites.
Liu Z, Wu J, Yu X.
Nature Structural & Molecular Biology 2007 Jul; 14(8):716.
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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ.
Science 2007 May; 316(5828):1194.
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Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.
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