Tissue lysates of mouse liver (35 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with OAT monoclonal antibody, clone AT23A2 (Cat # MAB8480) (1 : 1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Immunofluorescence of human HeLa cells stained with OAT monoclonal antibody, clone AT23A2 (Cat # MAB8480) (1 : 500) with Texas Red (Red). Nucleus was stained by Hoechst 33342 (Blue).
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme is the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. [provided by RefSeq