STX1A monoclonal antibody, clone SP8
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Specification
Product Description
Mouse monoclonal antibody raised against native STX1A.
Immunogen
Native purified human brain STX1A.
Host
Mouse
Theoretical MW (kDa)
36
Reactivity
Hamster, Human, Pig, Rat
Specificity
This antibody has been directly tested for reactivity in human, rat, pig, and hamster. This antibody is specific to the ~ 36 KDa syntaxin protein in Western blots of rat brain lysate. This antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 0.1 mg/mL BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of rat cortex lysate showing specific immunolabeling of the ~ 36k syntaxin STX1A protein. STX1A monoclonal antibody, clone SP8 (Cat # MAB8435).Immunohistochemistry
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Gene Info — STX1A
Entrez GeneID
6804Protein Accession#
Q16623Gene Name
STX1A
Gene Alias
HPC-1, STX1, p35-1
Gene Description
syntaxin 1A (brain)
Omim ID
186590Gene Ontology
HyperlinkGene Summary
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex.
Castillo MA, Ghose S, Tamminga CA, Ulery-Reynolds PG.
Biological Psychiatry 2009 Sep; 67(3):208.
Application:WB-Ti, Human, Rat, Human brain, Rat brain.
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Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Sudhof TC.
Journal of Neuroscience 2007 Nov; 27(45):12147.
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Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex.
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