TPO monoclonal antibody, clone 6H7
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Specification
Product Description
Mouse monoclonal antibody raised against TPO.
Immunogen
Purified human TPO.
Host
Mouse
Reactivity
Human
Specificity
These antibodies react specifically with human thyroid peroxidase.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TPO
Entrez GeneID
7173Gene Name
TPO
Gene Alias
MSA, TPX
Gene Description
thyroid peroxidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000115304|OTTHUMP00000115536|thyroid microsomal antigen|thyroperoxidase
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Pathway
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Disease
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