GSK3A monoclonal antibody, clone 6G12C2
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant GSK3A.
Immunogen
Recombinant protein corresponding to truncated human GSK3A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:500-1:2000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western blot analysis using GSK3A monoclonal antibody, clone 6G12C2 (Cat # MAB8308) against truncated GSK3A recombinant protein (Lane 1) and HeLa cell lysate (Lane 2).Enzyme-linked Immunoabsorbent Assay
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Gene Info — GSK3A
Entrez GeneID
2931Gene Name
GSK3A
Gene Alias
DKFZp686D0638
Gene Description
glycogen synthase kinase 3 alpha
Omim ID
606784Gene Ontology
HyperlinkGene Summary
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM
Other Designations
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Interactome
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Publication Reference
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Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells.
Mendez P, Garcia-Segura LM.
Endocrinology 2006 Jun; 147(6):3027.
Application:WB-Tr, Mouse, N2a cells.
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Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration.
Bianchi M, De Lucchini S, Marin O, Turner DL, Hanks SK, Villa-Moruzzi E.
The Biochemical Journal 2005 Oct; 391(Pt 2):359.
Application:WB-Tr, Rat, Rat fibroblasts.
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Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells.
De Servi B, Hermani A, Medunjanin S, Mayer D.
Oncogene 2005 Jul; 24(31):4946.
Application:IF, WB, Human, MELN cells.
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Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells.
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