EPHA1 monoclonal antibody, clone 5D2D1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of A-549 (Lane 1) and HeLa (Lane 2) cell extracts with EPHA1 monoclonal antibody, clone 5D2D1 (Cat # MAB8303).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embbed human ovary carcinoma (A) and breast carcinoma (B) tissue, showing cytoplasmic localization using EPHA1 monoclonal antibody, clone 5D2D1 (Cat # MAB8303).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant EPHA1.
Immunogen
Recombinant protein corresponding to truncated human EPHA1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:200-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
Immunohistochemistry (Frozen sections) (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of A-549 (Lane 1) and HeLa (Lane 2) cell extracts with EPHA1 monoclonal antibody, clone 5D2D1 (Cat # MAB8303).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embbed human ovary carcinoma (A) and breast carcinoma (B) tissue, showing cytoplasmic localization using EPHA1 monoclonal antibody, clone 5D2D1 (Cat # MAB8303).Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — EPHA1
Entrez GeneID
2041Gene Name
EPHA1
Gene Alias
EPH, EPHT, EPHT1, MGC163163
Gene Description
EPH receptor A1
Omim ID
179610Gene Ontology
HyperlinkGene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq
Other Designations
eph tyrosine kinase 1|ephrin receptor EphA1|ephrin type-A receptor 1|erythropoietin-producing hepatoma amplified sequence|oncogene EPH|soluble EPHA1 variant 1|soluble EPHA1 variant 2|tyrosine-protein kinase receptor EPH
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Interactome
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Pathway
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Disease
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Publication Reference
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Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer.
Inokuchi M, Nakagawa M, Baogok N, Takagi Y, Tanioka T, Gokita K, Okuno K, Kojima K.
Anticancer Research 2018 Mar; 38:1685.
Application：IHC, Human, Gastric cancers.
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Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development.
Duffy SL, Steiner KA, Tam PP, Boyd AW.
Gene Expression Patterns 2006 Oct; 6(7):719.
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Eph receptor signalling casts a wide net on cell behaviour.
Pasquale EB.
Nature Reviews. Molecular Cell Biology 2005 Jun; 6(6):462.
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Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer.
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