Products

Western Blot

Western blot analysis using DNM1 monoclonal antibody, clone 3G4B6 (Cat # MAB8301) against truncated DNM1 recombinant protein (Lane 1), SK-N-SH (Lane 2) and NIH/3T3 (Lane 3) cell lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human lymph tissue (A), glioma tissue (B) and cerebellum tissue (C), showing membrane localization using DNM1 monoclonal antibody, clone 3G4B6 (Cat # MAB8301) with DAB staining.

Immunohistochemistry (Frozen sections)

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

1759

Gene Name

DNM1

Gene Alias

DNM

Gene Description

dynamin 1

Omim ID

602377

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq

Other Designations

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