Mouse monoclonal antibody raised against partial recombinant DNM1.
Recombinant protein corresponding to truncated human DNM1.
Western Blot (1:500-1:2000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:2000) Immunohistochemistry (Frozen sections) (1:500-1:2000) ELISA (1:10000) The optimal working dilution should be determined by the end user.
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
Immunohistochemical analysis of paraffin-embedded human lymph tissue (A), glioma tissue (B) and cerebellum tissue (C), showing membrane localization using DNM1 monoclonal antibody, clone 3G4B6 (Cat # MAB8301) with DAB staining.
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq