CIB1 monoclonal antibody, clone 5A1F5E12, 5A1H7E12
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More Files
- More Functions
Western Blot
Western blot analysis using CIB1 monoclonal antibody, clone 5A1F5E12, 5A1H7E12 (Cat # MAB8297) against truncated CIB1 recombinant protein (Lane 1) and A-431 cell lysate (Lane 2).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human thalamus tissue (A) and glioma tissue (B), showing membrane localization using CIB1 monoclonal antibody, clone 5A1F5E12, 5A1H7E12 (Cat # MAB8297) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant CIB1.
Immunogen
Recombinant protein corresponding to truncated human CIB1.
Host
Mouse
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:500-1:2000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:2000)
Immunohistochemistry (Frozen sections) (1:500-1:2000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis using CIB1 monoclonal antibody, clone 5A1F5E12, 5A1H7E12 (Cat # MAB8297) against truncated CIB1 recombinant protein (Lane 1) and A-431 cell lysate (Lane 2).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human thalamus tissue (A) and glioma tissue (B), showing membrane localization using CIB1 monoclonal antibody, clone 5A1F5E12, 5A1H7E12 (Cat # MAB8297) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CIB1
Entrez GeneID
10519Gene Name
CIB1
Gene Alias
CIB, KIP, KIP1, SIP2-28
Gene Description
calcium and integrin binding 1 (calmyrin)
Omim ID
602293Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). [provided by RefSeq
Other Designations
DNA-dependent protein kinase interacting protein|Snk interacting protein 2-28|calcium and integrin binding 1|calcium and integrin binding protein|calcium and integrin binding, protein kinase interacting protein|calmyrin
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Interactome
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Disease
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Publication Reference
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The interaction between calcium- and integrin-binding protein 1 and the alphaIIb integrin cytoplasmic domain involves a novel C-terminal displacement mechanism.
Yamniuk AP, Ishida H, Vogel HJ.
The Journal of Biological Chemistry 2006 Sep; 281(36):26455.
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CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel.
White C, Yang J, Monteiro MJ, Foskett JK.
The Journal of Biological Chemistry 2006 Jul; 281(30):20825.
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Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.
Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV.
The Journal of Biological Chemistry 2005 Mar; 280(9):8407.
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The interaction between calcium- and integrin-binding protein 1 and the alphaIIb integrin cytoplasmic domain involves a novel C-terminal displacement mechanism.
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