IL31 monoclonal antibody, clone SB118b
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant IL31.
Immunogen
Recombinant protein corresponding to human TNFSF10.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (0.1-1.0 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.0
Storage Instruction
Store at 4°C.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL31
Entrez GeneID
386653Gene Name
IL31
Gene Alias
IL-31
Gene Description
interleukin 31
Omim ID
609509Gene Ontology
HyperlinkGene Summary
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S.
Gut 2007 Sep; 56(9):1257.
Application：IF, WB-Ce, Human, HCT-116, HT-29, SW480 cells.
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Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.
Broxmeyer HE, Li J, Hangoc G, Cooper S, Tao W, Mantel C, Graham-Evans B, Ghilardi N, de Sauvage FJ.
Experimental Hematology 2007 Apr; 35(4 Suppl 1):78.
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IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.
Perrigoue JG, Li J, Zaph C, Goldschmidt M, Scott P, de Sauvage FJ, Pearce EJ, Ghilardi N, Artis D.
The Journal of Experimental Medicine 2007 Mar; 204(3):481.
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Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
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