Human PBMC stimulated with (red line) orwithout (dotted line) PMA/ionomycin, thenblocked with an MMP7 inhibitor. Cells werethen stained with FASLG monoclonal antibody, clone SB93a1-FITC at 1 ug/mL dilution.
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq