CASP8 monoclonal antibody, clone SB125a
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Specification
Product Description
Rat monoclonal antibody raised against native CASP8.
Immunogen
Native purified human CASP8.
Host
Rat
Reactivity
Human
Form
Liquid
Isotype
IgM
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.0
Storage Instruction
Store at 4°C.
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Applications
Western Blot (Cell lysate)
Jurkat cells stimulated with STS. Cell lysate wasstained with CASP8 monoclonal antibody, clone SB125a (Cat # MAB8217). HRP conjugated Goat anti-Rat IgM was used to develop. -
Gene Info — CASP8
Entrez GeneID
841Gene Name
CASP8
Gene Alias
ALPS2B, CAP4, FLICE, FLJ17672, MACH, MCH5, MGC78473
Gene Description
caspase 8, apoptosis-related cysteine peptidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
Other Designations
FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|OTTHUMP00000163718|OTTHUMP00000163719|OTTHUMP00000163720|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8
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Interactome
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Pathway
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Disease
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Publication Reference
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The enigma of caspase-2: the laymen's view.
Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A.
Cell Death and Differentiation 2008 Nov; 16(2):195.
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Caspase-8 serves both apoptotic and nonapoptotic roles.
Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D.
Journal of Immunology 2004 Sep; 173(5):2976.
Application:WB-Ti, Mouse, Mouse liver.
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The enigma of caspase-2: the laymen's view.
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